Category: 12150-46-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

To a dichloromethane solution (15 cm3) of dppf (189 mg, 0.34 mmol), a methanolic solution of Na2PdCl4 (100 mg, 0.34 mmol) was added with continuous stirring. The resulting reaction mixture was refluxed for 8 hours. The solvents were evaporated in vacuo and the residue was washed thoroughly with diethyl ether to remove excess phosphine. The residue was extracted with dichloromethane, filtered and passed through a Florisil column. The resulting solution on refrigeration at ?5 oC afforded reddish orange crystals.(yield 214 mg, 86percent). Anal. Calcd. for C34H28P2FePdCl2?: C, 55.81?; H, 3.86?percent. Found: C, 55.86; H, 3.85?percent. 1H NMR (CDCl3) delta: 4.26 (br, 4H, C5H4), 4.71 (br, 4H, C5H4), 7.41-7.49 (m, Ph), 7.56-7.82 (m, Ph); 31P{1H}NMR (CDCl3) delta?: 34.1 ppm.

The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chauhan, Rohit Singh; Cordes, David B.; Slawin, Alexandra M.Z.; Yadav, Seema; Dash, Chandrakanta; Inorganica Chimica Acta; vol. 478; (2018); p. 125 – 129;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

To a colourless solution of [(C6F5)2Pt(mu-PPh2)2Pt(NCMe)2] (0.150g, 0.127mmol) in acetone (5mL) was added dppf (0.071g, 0.127mmol). The resulting yellow solution was stirred at room temperature for 1h and then evaporated to 2mL. Complex 1 crystallized as a yellow solid, which was filtered, washed with Et2O (2¡Á2mL) and vacuum-dried. Yield: 0.178g, 85percent. Anal. Found (Calc. for C70H48F10FeP4Pt2): C, 51.07 (50.99); H, 3.08 (2.93). IR (Nujol, cm?1): 1161 (vs), 821 (s) dppf; 952 (vs), 781(vs) (Fermi res., C6F5), 772 (vs) (X-sensitive C6F5). 1H NMR (thf-d8, 295K, 400MHz): delta 4.10 (s, CbetaH, 4H), 4.41 (s, CgammaH, 4H), from 6.5 to 8.5 (m, Ph, 40H). 19F NMR (thf-d8, 300K, 376.5MHz): delta ?116.7 (4 o-F, 3JF,Pt(1)=325Hz), ?168.8 (m, 4 m-F), ?169.6 (t, 2 p-F, 3JF,F=20Hz); 31P{1H} NMR (thf-d8, 295K, 162MHz): delta 12.0 (m, 2JP(3),P(1)=2JP(4),P(2)=239Hz, 2JP(3),P(4)=55Hz, 2JP(3),P(2)=2JP(4),P(1)=14Hz, 1JP,Pt=2210Hz, P3/4), ?98.6 (m, 2JP(1),P(3)=2JP(2),P(4)=239Hz, 2JP(1),P(2)=111Hz, 2JP(1),P(4)=2JP(2),P(3)=14Hz, 1JP,Pt(1)=1802Hz, 1JP,Pt(2)=1745Hz, P1/2) ppm. 195Pt{1H} NMR (thf-d8, 295K, 86MHz): delta ?3761 (m, Pt1), ?4235 (m, Pt2), ppm.

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Giardina-Papa, Daniela; Ara, Irene; Ibanez, Susana; Mastrorilli, Piero; Gallo, Vito; Fornies, Juan; Polyhedron; vol. 120; (2016); p. 44 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: DMPE (102 muL, 0.616 mmol) was slowly added to a yellow suspension of [Pd(TFA)2(TMEDA)] (0.138 g, 0.31 mmol) in CH2Cl2 (3 mL). An initial suspension turned gray. After stirring the reaction mixture for 2 h at room temperature, the solvent was removed under vacuum, and washed with n-hexane. The crude solid was recrystallized from CH2Cl2/hexane to give [Pd(P~P)2](TFA)2 (P~P = DMPE), 2 (0.192 g, 99percent). Complexes 3?8 were analogously prepared. Analytical and spectroscopic data are available as Supporting Information.

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Kim, Kun-Woo; Kim, Yong-Joo; Lim, Hye Jin; Lee, Soon W.; Bulletin of the Korean Chemical Society; vol. 36; 12; (2015); p. 2952 – 2955;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 7-Carbomethoxy-benzopyran-4-one To a stirred solution of 7-trifluoromethylsulfonyloxy-benzopyran-4-one (7.89 g, 26.6 mmole) in DMF (54 ml) was added methanol (21.6 ml), palladium acetate (110 mg, 0.533 mmole), DPPF (590 mg, 1,066 mmole) and triethylamine (7.477 ml, 53.3 mmole). Carbon monoxide gas was bubbled through the solution for 5 minutes, and the mixture was stirred at 50¡ã C. for 3 hours under 1 atmosphere of CO. After cooling, the mixture was poured into 120 ml of 1M sulfuric acid and extracted with 2*75 ml of ethylacetate. The combined organic fractions were washed with brine, dried over MgSO4, and filtered. Solvent evaporation in vacuo and chromatography (silica gel 1:1 hexane:ether) gave 5.19 g of the title compound (94percent yield). 1 H-NMR (300 MHz, CDCl3): 7.96 (1H, d, J=9.2 Hz), 7.60-7.65 (2H, m), 4.6 (2H, t, J=6.7 Hz), 2.88 (2H, t, J=6.7 Hz).

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5550152; (1996); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate