Category: 12150-46-8

12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 12150-46-8, Application In Synthesis of 1,1-Bis(diphenylphosphino)ferrocene

The remarkable stability of BF4 , characterized in the solid state by X-ray analysis and in solution by 31P NMR spectroscopy, reveals a marked borderline character of Cu(I).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 1,1-Bis(diphenylphosphino)ferrocene. In my other articles, you can also check out more blogs about 12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8, category: chiral-phosphine-ligands

Reactions of the cationic complex ions [PtMe(Me2SO)(PP)] + (PP = dppf (1,1?-bis(diphenylphosphino)ferrocene) and dppe (1,2-bis(diphenylphosphino)ethane)) with 5,10,15,20-tetrakis(4-pyridyl)-21H,23H- porphyrin (TpyP) led to the formation of the symmetrical tetraplatinated porphyrin complexes, [PtMe(PP)]4TpyP·X4 (PP = dppf, X = CF3SO3-, 3, and PP = dppe, X = BF 4-, 5) containing the organometallic fragment {PtMe(PP)}. The precursor sulfoxide platinum complexes [PtMe(Me2SO)(dppf)]CF 3SO3, 2 and [PtMe(Me2SO)(dppe)]BF4, 4, were prepared by halide abstraction from [PtMeCl(dppf)], 1, and by controlled protonolysis of [PtMe2(dppe)] respectively, in the presence of a small amount of dimethyl sulfoxide. All these starting platinum(ii) compounds, as well as the porphyrin derivatives 3 and 5, were fully characterized through elemental analysis, 1H NMR mono- and bidimensional, 31P{1H}, 31P-1H HMBC, UV/Vis absorption and photophysical measurements. The X-ray crystal structure of complex 1 has been determined. In order to ascertain the electronic influence of ferrocene, the spectroscopic and redox properties of 3 were compared with those of TPyP and of the analogous 5. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), 1H and 31P NMR data, and UV/Vis data, all suggest a certain degree of communication between the central porphyrin and the peripheral hetero-bimetallic fragments. In contrast, no detectable interaction among these peripheral groups seem to come into play. Unlikely from the porphyrin derivative 5, formation of well defined fluorescent mesoscopic ring structures was easily achieved by simple evaporation from diluted dichloromethane solutions of 3. The Royal Society of Chemistry 2006.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 12150-46-8 is helpful to your research., category: chiral-phosphine-ligands

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8, Application In Synthesis of 1,1-Bis(diphenylphosphino)ferrocene

Palladium catalyzed Negishi, Suzuki and Stille cross-coupling reactions of enantiopure 2,2?-diiodo-1,1?-binaphthyl with the corresponding 1,1?-dimetalloferrocenes gave the C2-symmetric binaphthyl bridged ferrocene 1-1,1?-(1,1?-binaphthyl-2,2?-diyl)ferrocene (1). The latter was obtained by Stille coupling with the bis(trimethylstannyl) derivative but not with the bis(tributylstannyl) one. Products of alkyl group transfer from tin to binaphthyl were obtained as the main products in both cases. The stereochemical result of these cross-coupling reactions in the positions 2 and 2? of 1,1?-binaphthyl depends on the reactivity of 1,1?-dimetalloferrocenes. Negishi coupling proceeds stereoconservatively (affording enantiopure product 1). Complete racemization of binaphthyl moiety occurs during the reactions with less reactive boron and tin organometallics. Proposed different reaction pathways include C1-symmetric palladium(II) intermediate in the former and configurationally unstable C2-symmetric pallada(IV)cyclic intermediate in the latter cases. In contrast to the cross-coupling reactions, free radical arylation of ferrocene with enantiopure 1,1?-binaphthyl-2,2?-bisdiazonium salt gave predominantly oligomeric binaphthyl bridged ferrocenes and only traces of the partially racemized product 1.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 1,1-Bis(diphenylphosphino)ferrocene. In my other articles, you can also check out more blogs about 12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In an article, published in an article, once mentioned the application of 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene,molecular formula is C34H28FeP2, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 1,1-Bis(diphenylphosphino)ferrocene

The present invention relates to novel 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2H-[1,4]oxazin-3-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer’s disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebral amyloid angiopathy, multi-infarct dementia, Down’s syndrome, dementia associated with stroke, dementia associated with Parkinson’s disease and dementia associated with beta-amyloid.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 12150-46-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8

A transition metal-catalyzed intermolecular hydroamination of vinylarenes with alkylamines is reported. The combination of Pd(O2CCF3)4, DPPF, and TfOH was the most effective catalyst of those tested. Control experiments without palladium, acid, or ligand all occurred in low yield. The reaction of various vinylarenes with cyclic and acyclic alkylamines in the presence of 5 mol % of this catalyst formed the corresponding arylethylamine products in moderate to high yields. For example, reactions of morpholine, 4-phenylpiperazine, 4-Boc-piperazine, isoindoline, and tetrahydroisoquinoline with styrene all occurred in 58?75% yield. Acyclic amines such as N-benzylmethylamine and n-hexylmethylamine reacted with 2-vinylnaphthalene in 63% and 53% yields, respectively. Mechanistic investigations showed that the reaction occurred through an eta3-arylethyl palladium complex. The reactions of this complex with alkylamines generated product in combination with regenerating free vinylarene, Pd(0), and ammonium salt. Thus, one hurdle to developing hydroamination of vinylarenes with palladium complexes is the faster elimination of free vinylarene from the eta3-arylethyl complex than addition to form the C?N bond. The feasibility of conducting enantioselective hydroaminations with alkylamines was also examined. The product from addition of N-benzylmethylamine to 2-vinylnaphthalene was generated in 63% ee and 36% yield in the presence of Pd(OCOCF3)2, a ferrotane ligand, and TfOH cocatalyst. Copyright

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 12150-46-8 is helpful to your research., Reference of 12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application of 12150-46-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8

Group 7-12 transition-metal complexes serve as effective catalysts for the regioselective intramolecular hydroamination of aminoalkynes having the general formula RC?C(CH2)n-NH2 (n = 3, R = H, Ph; n = 4, R = H) and of 2-(phenylethynyl)aniline. Primary products are pyrrolidines and piperidines bearing an alpha-alkylidene functionality and 2-phenylindole, respectively. Isomerization yields the corresponding pyrrolines and 1,2-dehydropiperidines. The catalytic properties of the transition-metal complexes depend on the appropriate choice of ligand, solvent, temperature, and counteranion. Principles for identifying the most active transition-metal catalysts for the hydroamination of alkynes and for optimizing the reaction conditions are developed. The X-ray crystal structure of one catalyst, [PdCl(triphos)](CF3-SO3), has been determined.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 12150-46-8 is helpful to your research., Application of 12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 12150-46-8, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a patent, introducing its new discovery.

A series of platinum(II), palladium(II) and nickel(II) complexes containing thiosalicylate ligands have been prepared by the reaction of [MX2L2] complexes [X = halide or acetate; L or L2 = ancillary neutral donor ligand such as a tertiary phosphine or cycloocta-1,5-diene (cod)] with thiosalicylic acid in methanol with added pyridine. Displacement of the cod ligand from [Pt(SC6H4CO2)(cod)] with phosphines and phosphites allows the synthesis of additional derivatives. The complexes [Pt(SC6H4CO2)(PPh3)2] and [Ni(SC6H4CO2)(dppp)] [dppp = 1,3-bis(diphenylphosphino)propane] have been the subjects of single-crystal X-ray diffraction studies. While both complexes contain the expected approximately square-planar metal co-ordination environments, the plane of the thiosalicylate ligand is inclined at an angle of 45.9 to the platinum co-ordination plane, but at only 9.4 to the nickel plane. The results of an electrospray mass spectrometry study of the thiosalicylate complexes and some related thioglycolate, 2-sulfanylpropionate and salicylate derivatives are discussed in terms of the stabilities of the complexes.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 12150-46-8. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene. In a document type is Article, introducing its new discovery.

The preparation of heteroleptic Cu complexes from various 2,9-disubstituted-1,10-phenanthrolines (phen) and different bis-phosphine (PP) ligands was investigated. These heteroleptic complexes are found to be stable in CH2Cl2 solutions and no detectable ligand exchange reactions could be detected. The results also show that the CuI-mediated threading of all the bis-phosphine ligands through the macrocycle is effective. The X-ray crystal structure analysis of BF4 proves the threading of the POP moiety through the macrocyclic phenanthroline ligand. The intramolecular face-to-face p p interaction between one phenyl ring of the POP ligand and the phenanthroline moiety induces a significant rocking of the POP ligand. The results also show that formation of the homoleptic bisphenanthroline Cu complex is prevented by the macrocyclic nature of the phenanthroline ligand.

If you are interested in 12150-46-8, you can contact me at any time and look forward to more communication.Reference of 12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8, Quality Control of: 1,1-Bis(diphenylphosphino)ferrocene

A 1,1? bis(diphenylphosphino ferrocene)dioxide complex of uranyl nitrate was synthesized and characterized by IR, 1H and 31P{1H} NMR spectroscopic and X-ray diffraction methods. The structure of the compound shows that the uranium atom is surrounded by eight oxygen atoms in a hexagonal bi-pyramidal geometry. Two oxygen atoms from 1,1? bis(diphenylphosphino ferrocene)dioxide ligand and four oxygen atoms from the nitrate groups form a planar hexagon. The two uranyl oxygen atoms occupy the axial position. The 1,1? bis(diphenylphosphino ferrocene)dioxide ligand acts as a bidentate chelating ligand with a bite angle of 71.56(8) around the uranium(VI) atom, which is much smaller in value compare to any of the previously reported values (90.1-154.0) for this ligand.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 12150-46-8 is helpful to your research., Quality Control of: 1,1-Bis(diphenylphosphino)ferrocene

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8, SDS of cas: 12150-46-8

Interaction of Ru5C(CO)15 with C60 in refluxing chlorobenzene followed by PPh3 or dppe (1,2-bis(diphenylphosphino)ethane) forms Ru5C(CO)11(PPh3)(mu3-eta 2,eta2,eta2-C60) (1) or Ru5C(CO)10-(mu-eta1,eta 1-dppe)(mu3-eta2,eta 2,eta2-C60) (2), isolated in 19% and 14% yields, respectively, after chromatography. An analogous reaction of Ru5C(CO)15 with C60 followed by dppf (1,1?-bis(diphenylphosphino)ferrocene) initially forms both Ru5C(CO)11(eta1-dppf)(mu 3-eta2,eta2,eta2-C 60) (3) and Ru5C(CO)10(mu-eta1,eta 1-dppf)(mu3-eta2,eta 2,eta2-C60) (4), but further thermolysis of 3 in refluxing chlorobenzene converts it to 4. Direct interaction of Ru5C(CO)14(PPh3) (5), Ru5C(CO)13(dppe) (6), and Ru5C(CO)13(dppf) (7) with C60 in refluxing chlorobenzene also provides 1, 2, and 4 in isolated yields of 21%, 27%, and 20%, respectively. Interaction of PtRu5C(CO)16 or PtRu5C-(CO)14(COD) with C60 followed by dppe in refluxing chlorobenzene forms PtRu5C(CO)11(eta2-dppe)(mu 3-eta2,eta2neta2-C 60) (8) (7% and 23% yields, respectively). Substitution of the COD ligand in PtRu5C(CO)14(COD) by dppe at room temperature provides PtRu5C(CO)14(eta2-dppe) (9). Compound 9 does not react with C60 to give 8. All new compounds have been characterized by a combination of analytical and spectroscopic methods, and the molecular structures of compounds 1, 2, 4, 7, 8, and 9 have been determined by single-crystal X-ray diffraction studies.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 12150-46-8, you can also check out more blogs about12150-46-8

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate