Category: 1079-66-9

Brief introduction of 1079-66-9

As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 330 g (7.17 mol) of absolute ethanol are cooled to -15 C. under a nitrogen atmosphere. 26.5 g (1.56 mol) of ammonia gas are introduced thereto at this temperature with constant stirring. 200 g (0.907 mol) of chloro(diphenyl)-phosphine are then added dropwise at this temperature. The mixture is then allowed to come to room temperature with stirring and is then kept under reflux for 11 hours until virtually no more ammonia gas escapes. The mixture is then cooled, filtered by suction, washed with ethanol and dried. 48 g of crude ammonium chloride are obtained. The filtrate is freed from ethanol and any ammonia present in vacuo. The remaining residue is freed from a slight salt precipitate by filtration through a glass frit. 170 g of ethyl diphenylphosphinite are then obtained by thin film distillation at a bath temperature of 160 to 175 C. and a pressure of 0.5 mbar. This corresponds to a yield of 82% of theory., 1079-66-9

As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5705669; (1998); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Brief introduction of 1079-66-9

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2; To 250 ml three-necked bottle were added 50 ml tetrahydrofuran and 1.1 g metallic sodium, 4.4 g chlorodiphenylphosphine. The mixture reacted at 35¡ã C. for 2.5 h so that chlorodiphenylphosphine reacted completely to form diphenylphosphine sodium, the temperature was dropped to 0¡ã C., the resulted mixture was added to 100 ml tetrahydrofuran system containing 6.3 g lithium o-chlorobenzoate and reacted for 3 h to form lithium diphenylphosphinobenzoate, and then concentrated hydrochloric acid was added to perform hydrolysis, followed by concentration, 3.1 g o-diphenylphosphinobenzoic acid was obtained, HPLC=98.9percent, yield was 50.5percent.

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; GAO, Jianxun; Luo, Junlu; Wang, Bibo; Wang, Yamin; Dong, Hongrong; Zhou, Dong; Xu, Lei; Shi, Jinbiao; US2011/77426; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Analyzing the synthesis route of 1079-66-9

1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

At room temperature under argon, a solution of sec-BuLi (22 mL, 1.3 mol dm-3, 0.029 mol, 3 eq) in hexane is added dropwise to a stirred solution of diphenyl ether (1.6 g, 9.5.x.10-3 mol, 1 eq) and tetramethylethylenediamine (TMEDA, 3.4 g, 0.029 mol, 3 eq) in dry degassed diethyl ether and stirred for 16 hours. A solution of chlorodiphenylphosphine (5.2 mL, 0.029 mol, 3 eq) in hexane is then added dropwise, and the reaction mixture stirred for a further 16 hours. The solvent is removed under reduced pressure, and the resulting oil dissolved in CH2Cl2, washed with water and dried with MgSO4. The solvent is removed under reduced pressure, and the resulting yellow oil is recrystallized from ethanol to yield 2,2′-bis(diphenylphosphino)diphenyl ether.

1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; White, Daniel F.; US2011/124904; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 1079-66-9

1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,1L three bottles,From 50 g of 4-bromo-N, N-dimethylaniline,7 g of magnesium turnings and 400 ml of anhydrousTHF to produce Grignard reagent,Refluxed for 10 hours, reduced to room temperature,2.9 g of tetrakis (triphenylphosphine) palladium was added,Stirred for 3 hours,61 g of diphenylphosphonium chloride was added dropwise at room temperature,The reaction was refluxed for 8 hours.And the mixture was added dropwise to the reaction solution under ice-water bath200 mL of saturated aqueous ammonium chloride was quenched,Liquid separation, the organic phase solution,Add methanol crystallization,And filtered to obtain 74 g of white 4- (N, N-dimethylamino) diphenylphosphine benzene,Yield 96percent.

1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Panjin Gelin Kaimo Technology Co., Ltd.; Rao, Zhihua; Gong, Ningrui; (12 pag.)CN105859774; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate