Category: 1070663-78-3

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, EXAMPLE TWELVE: Synthesis of Precatalyst 10; Ligand 1 (BrettPhos)An oven-dried schlenk tube, which was equipped with a magnetic stir bar and fitted with a rubber septum, was charged with Me2Pd(TMEDA) (253 mg, 1 mmol) and 1 (537 mg, 1 mmol). The vessel was evacuated and backfilled with argon (this process was repeated a total of 3 times) and the 2-(2-chorophenyl)ethylamine (156 mg, 1 mmol) and MTBE (8 mL) were added via syringe and the reaction mixture was heated to 55 0C for 5 h. The reaction mixture was then cooled to 0 0C and a white precipate was filtered and washed with cold MTBE. The white product was then taken up in CH2Cl2 and concentrated under reduced pressure (done to remove any remaining MTBE) to yield the product as a white solid (645 mg, 93% yield). 1H NMR (300 MHz, CDCl3) delta: 7.17 (s, 2H), 7.09-6.84 (m, 6H), 3.85 (s, 3H), 3.38 (s, 3H), 3.17-0.00 (m, 49 H) ppm. 31P NMR (121 MHz, CDCl3) delta: 42.2 ppm. IR (neat, cm”1): 3303, 2929, 1658, 1462, 1384, 1256, 1010, 755.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, [(i3-indenyl)Pd(.i-OTf)j2 (0.10 g, 0.135 mmol) and BrettPhos (0.145 g, 0.270 mmol) were added to a 20 mL vial equipped with a flea stir bar. THF (10 mL) was added to the vialand a red homogenous mixture was observed. The mixture was stirred for one hour at room temperature, at which time the solvent was removed under reduced pressure. The red oil was titrated with pentane to yield a dark red solid. Yield: 0.220 g, 90%. 1H NMR (CDCl3, 500 MHz): 7.44 (s, 1H), 7.16-6.93 (m, 7H), 6.82 (d, J = 6.5 Hz, 1H), 6.63 (s, 1H), 6.06 (s, 1H), 4.17 (d, 5.4 Hz, 1H), 3.92 (s, 3H), 3.33 (s, 3H), 3.15 (sept, J = 5.6 Hz, 1H), 2.79 (q, J = 5.7Hz, 1H), 2.56 (q, J = 5.7 Hz, 1H), 2.27-1.67 (m, 16H), 1.54-0.81 (m, 20H), 0.69 (d, J = 6.1Hz, 3H), 0.45 (d, J = 6.2 Hz, 3H) ppm. 13C{1H} NMR (126 MHz, CDCl3): 154.85, 154.17,153.51, 151.21, 151.08, 150.96, 139.93, 139.89, 135.74, 135.33, 134.74, 134.58, 129.16,127.13, 125.74, 125.47, 124.60, 122.89, 122.59, 120.93, 119.38, 116.60, 116.43, 115.46,114.21, 114.16, 112.88, 112.84, 109.62, 109.58, 70.76, 67.95, 56.04, 54.71, 39.16, 38.98,38.71, 38.51, 34.38, 34.19, 32.77, 32.21, 31.94, 30.53, 30.51, 30.30, 29.79, 29.24, 27.35,27.25, 27.09, 26.99, 26.87, 26.79, 26.75, 26.67, 26.42, 25.83, 24.93, 24.61, 24.31, 24.16,23.85 ppm. 31P{1H} NMR (CDCl3 100 MHz): 58.19 ppm. 19F NMR (471 MHz, CDCl3):-78.01 ppm.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; YALE UNIVERSITY; HAZARI, Nilay; MELVIN, Patrick; (59 pag.)WO2018/183328; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, EXAMPLE FORTY-FOUR: Synthesis of BrettPhosPdPhCl (18); In a nitrogen filled glovebox, a solution of BrettPhos (1, 51.0 mg, 96 mumol), chlorobenzene (100 muL) and THF (4 mL) was added to solid (COD)Pd(CH2SiPhMe2^ (40.8 mg, 80 mumol) in an oven-dried 20 mL vial. The vial was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (14 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 18 (42 mg, 69%) as light-yellow microcrystalline powder: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.28-7.30 (m, 2H – minor), 7.07-7.10 (m, 2H – minor), 7.04 (s, 2H – major), 7.02 (s, 2H – minor), 6.82-6.92 (m, major and minor), 6.76-6.82 (m, IH – minor, IH – major), 4.29 (s, 3H – minor), 3.79 (s, 3H -major), 3.59 (s, 3H – minor), 3.34 (s, 3H – major), 2.96-3.03 (m, IH – major), 2.88-2.95 (m, IH – major), 2.71-2.80 (m, 2H – major), 2.46-2.53 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 1.50-1.90 (m, major and minor), 1.08-1.45 (m), 0.78-0.92 (m, major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 46.8 (minor), 38.6 (major). Anal CaIc for C4iH58C102PPd: C, 65.16; H, 7.74;. Found: C, 65.42; H, 7.53.

As the paragraph descriping shows that 1070663-78-3 is playing an increasingly important role.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, EXAMPLE FORTY-THREE: Synthesis of BrettPhosPdPhBr (17); In a nitrogen filled glovebox, a solution of BrettPhos (1, 23.6 mg, 44 mumol), bromobenzene (30 muL) and THF (2 mL) was added to solid (COD)Pd(CH2SiPhMe2)2 (20.4 mg, 40 mumol) (COD = 1,5-cyclooctadiene) in an oven-dried 20 mL vial. (The THF used in this experiment was prepared as escribed in the general procedures set forth in Example 7, then sparged with N2 for 30 min and stored over activated 3 A molecular sieves in a glovebox prior to use.) Pan, Y.; Young, G. B. J Organomet. Chem. 1999, 577, 257 ‘. The vial was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (8 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 17 (24 mg, 75%) as light-yellow needles as a THF mono-solvate: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.26-7.29 (m, 2H – minor), 7.00-7.06 (m, major and minor), 6.82- 6.92 (m, major and minor), 6.75-6.79 (m, IH – minor, IH – major), 4.33 (s, 3H – minor), 3.79 (s, 3H -major), 3.59 (s, 3H – minor), 3.33 (s, 3H – major), 3.00-3.08 (m, IH – major), 2.88-2.92 (m, IH – major), 2.72-2.82 (m, 2H – major), 2.46-2.53 (m, 2H – major), 2.32- 2.37 (m, 2H -minor), 1.50-1.90 (m, major and minor), 1.05-1.45 (m), 0.75-0.90 (m, 12H – major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 44.9 (minor), 36.9 (major).

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, [Pd(allyl)(brettphos)]OTf was synthesized according to the literature.[4] A dry Schlenk flask equipped with a Teflon-coated magnetic stirring bar was charged with [(allyl)PdCl]2 (183 mg, 0.5 mmol) followed by AgOTf (257 mg, 1.0 mmol). The flask was fitted with a rubber septum, evacuated, and backfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated two additional times. Solvent (10 mLof THF) was added, and the reaction mixture was stirred at room temperature for 30min while protected from light. A second dry Schlenk flask was equipped with a magnetic stirring bar, fitted with a Schlenk frit, and charged with BrettPhos (537 mg,1.0 mmol). The flask was fitted with a rubber septum, and it was evacuated andbackfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated twoadditional times. The solution from the first Schlenk flask was transferred through amillipore filter (to remove AgCl) into the second Schlenk flask containing the ligand,rinsing with 5 mL of additional solvent (THF). This mixture was stirred at roomtemperature for 2 h. Hexanes (450 mL) was then added to the mixture to fullyprecipitate the product. The solid materials were then collected by suction filtration,washed with additional hexanes, and dried in vacuo to give 734 mg (86%) of the titlecompound as a yellow solid.

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Wentong; Kuang, Yi; Wang, Zhifan; Zhu, Jin; Wang, Yuanhua; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 542 – 550;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, General procedure: The general procedure is followed using 259 mg (0.50 mmol) of 33 [(cinnamyl)PdCl]2, 257 mg (1.00 mmol) of 22 AgOTf, 537 mg (1.00 mmol) of BrettPhos in anhydrous 2-MeTHF to give 884 mg (0.97 mmol, 97%) of the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3, delta): complex spectrum-see FIG. 5. 13C NMR (100 MHz, CDCl3, delta): complex spectrum-see FIG. 6. 31P NMR (162 MHz, CDCl3, delta): 57.6, 39.5. 19F NMR (376 MHz, CDCl3, delta): -78.1 (s, 3F). Anal. Calcd. for C45H62F3O5PPdS: C, 59.43; H, 6.87. Found: C, 59.26; H, 6.68.

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, EXAMPLE FORTY-FIVE: Synthesis of BrettPhosPd(3,5-dimethylphenyl)Br (19); In a nitrogen filled glovebox, a solution of BrettPhos (1, 172 mg, 321 mumol), 3,5- dimethylbromobenzene (225 muL) and THF (15 rnL) was added to solid (COD)Pd(CH2SiPhMe2)2 (150 mg, 292 mumol) in an oven-dried 100 mL round bottom flask. The flask was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (60 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 19 (185 mg, 77%) as light-yellow microcrystalline powder as a THF mono-solvate: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.01-7.08 (m, 2H – major, 4H – minor), 6.90 (s, 2H – minor), 6.89 (dd, J= 9.2, 2.8, IH – major), 6.83 (d, J= 8.8 Hz, IH -major), 6.64 (s, 2H – major), 6.41 (s, IH – minor, 2H – major), 4.31 (s, 3H – minor), 3.78 (s, 3H -major), 3.59 (s, 3H – minor), 3.32 (s, 3H – major), 3.03-3.06 (m, IH – major), 2.88-2.92 (m, IH – major), 2.70-2.79 (m, 2H – major), 2.45-2.51 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 2.14 (s, 6H -major), 2.12 (s, 6H – minor), 1.50-1.90 (m, major and minor), 1.05-1.45 (m), 0.75- 0.90 (m, 12H – major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 45.0 (minor), 37.5 (major). Anal CaIc C43H62BrO2PPd: C, 62.36; H, 7.55. Found: C, 62.52; H, 7.68.

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, General Procedure 1. A solution of BrettPhos (1.5 eq) and aryl bromide (6.0 eq) in THF (15 mL mmol-1) was added to a vial containing (COD)Pd(CH2TMS)2 (1.0 eq). The resulting yellow solution was stirred for 48 h and then layered with twice the volume of pentane and left standing. After 24 h, the resulting solid was filtered off, washed with pentane and dried under vacuum. Preparation of (BrettPhos)Pd(2-Me,4-CF3C6H3)(Br). According to general procedure 1, (COD)Pd(CH2TMS)2 (144 mg, 0.37 mmol) was reacted with BrettPhos (300 mg, 0.56 mmol) and 2-methyl-4-trifluoromethylbromobenzene (531 mg, 2.22 mmol) in 6 mL THF to afford 218 mg (247 mummol, 67%) of the desired complex as a white powder. 31P-NMR (162 MHz, CDCl3): delta=43.9 ppm. 19F-NMR (376 MHz): delta=-62.1 ppm. 1H (500 MHz, CDCl3): complex spectrum, shown in FIG. 9.

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; US2011/15401; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, mixing dimethyl sulfide gold chloride with a phosphine ligand BrettPhos in dichloromethane, stirring the reaction for 5 min at room temperature, filtering, and spinning, That is, the BrettPhosAuCl catalyst is obtained, and the ratio of the phosphine ligands BrettPhos, dimethyl sulfide, gold chloride, and dichloromethane is 1 mmol: 1 mmol: 1 mL;

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanyang Normal College; Li Ting; Li Bo; Yang Yuhan; Yang Ping; (9 pag.)CN109053654; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate