With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
50777-76-9, Under inert gas protection,50mLSchlenk reaction tube added2,9-dimethyl-4,7-bis (3,5-di (n-hexyl) phenyl) 1,10-phenanthroline (0.350g, 0.5mmol),2- (diphenylphosphino) benzaldehyde (0.291 g, 1 mmol)And potassium phosphate (1 mmol),A deoxygenated tetrahydrofuran (20 mL) was added,Room temperature reaction 48h,After completion of the reaction, the mixture was cooled to room temperature,50 mL of water was added to the reaction solution, the solid was precipitated and filtered, and the filtered solid was recrystallized from 1 mL of a crystalline solvent methanol,To give the title product 416 mg, yield 67percent
The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang University of Technology; Luo Shuping; Yu Zhejian; Chen Hao; Xia Liangmin; Wang Mingming; Wu Qingan; (8 pag.)CN106749411; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate