787618-22-8,787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 0846 A mixture of 7-bromo-N-(5-isopropylpyridazin-3-yl)-1,5-naphthyridine-2-amine (15 mg), pyrrolidine (11 muL), tris(dibenzylideneacetone)dipalladium(0) (4 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (4 mg), sodium tert-butoxide (13 mg), and tert-amyl alcohol (0.5 mL) was stirred at 130 C. for 30 minutes using a microwave reaction apparatus. The reaction mixture was cooled to room temperature, the insolubles were filtered off, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (methanol-ethyl acetate), thereby obtaining N-(5-isopropylpyridazin-3-yl)-7-(pyrrolidin-1-yl)-1,5-naphthyridine-2-amine (12 mg) as a yellow solid. 1H-NMR (CDCl3) delta: 8.79-8.75 (2H, m), 8.68 (1H, s), 8.37 (1H, d, J=2.6 Hz), 8.10 (1H, d, J=8.6 Hz), 7.22 (1H, d, J=8.6 Hz), 6.96 (1H, d, J=2.6 Hz), 3.52-3.45 (4H, m), 3.06-2.97 (1H, m), 2.14-2.09 (4H, m), 1.39 (6H, d, J=7.3 Hz). MS m/z (M+H): 335.
As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.
Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate