With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
General procedure: PR3 and NH4PF6 were added to a solution of fac-[RuCl3(NO)(P?N)] (1) in MeOH (5 mL) and the resulting orange suspensionwas refluxed for 3 h, except for the P(p-Me-C6H4)3 system whenreaction occurred at r.t. After being cooled to room temperature,the resulting yellow suspensions of complexes 3?5 were filteredto give a yellow solid that was washed with H2O (2 5 mL), MeOH(2 5 mL) and Et2O (2 5 mL), and then dried in vacuo. In the caseof complex 2, the reaction generated a clear yellow solution; thesolvent was removed in vacuo to give a yellow residue that wasthen largely dissolved in CH2Cl2 (5 mL), and the mixture wasfiltered through Celite. Addition of n-hexane (15 mL) yielded a yellowsolid that was then treated as described above. The mer, transisomerof 1 [6,7] could also be used as the precursor for synthesesusing the same methodology, which gave similar product yields., 18437-78-0
The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; da Silva, Juliana P.; Fagundes, Francisco D.; Back, Davi F.; Ellena, Javier; James, Brian R.; de Araujo, Marcio P.; Inorganica Chimica Acta; vol. 454; (2017); p. 40 – 45;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate