Copper-Catalyzed Asymmetric Hydroboration of 1,1-Disubstituted Alkenes was written by Wang, Zining;He, Xiaxia;Zhang, Rui;Zhang, Ge;Xu, Guoxing;Zhang, Qian;Xiong, Tao;Zhang, Qian. And the article was included in Organic Letters in 2017.Category: chiral-phosphine-ligands This article mentions the following:
A mild and efficient approach for highly regio- and enantioselective copper-catalyzed hydroboration of 1,1-diaryl substituted alkenes with bis(pinacolato)diboron (B2Pin2) was developed for the first time, providing facile access to a series of valuable β,β-diaryl substituted boronic esters with high enantiomeric purity. Moreover, this approach could also be suitable for hydroboration of α-alkyl styrenes for the synthesis of enantioenriched β,β-arylalkyl substituted boronic esters. Gram-scale reaction, stereospecific derivatizations, and the application of important antimuscarinic drug (R)-tolterodine for concise enantioselective synthesis further highlighted the attractiveness of this new approach. In the experiment, the researchers used many compounds, for example, (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2Category: chiral-phosphine-ligands).
(2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2) belongs to chiral phosphine ligands. The synthesis of novel trialkylphosphines can be quite difficult, thereby limiting the scope of their chiral variants. Indeed, very little research on chiral tertiary phosphine-catalyzed asymmetric reactions occurred prior to the year 2000.Category: chiral-phosphine-ligands
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis