Enantioselective Intramolecular Aza-Michael Additions of Indoles Catalyzed by Chiral Phosphoric Acids was written by Cai, Quan;Zheng, Chao;You, Shu-Li. And the article was included in Angewandte Chemie, International Edition in 2010.Application of 1043567-32-3 This article mentions the following:
An asym. intramol. aza-Michael addition of indoles catalyzed by chiral phosphoric acids is described. Enantioenriched tetrahydropyridoindoles, e.g. I (X = CH2, R = Cl, Me, MeO; X = NBoc, R = H), were obtained in high yields (72-98%) and enantioselectivities (69-93% ee). Sequential olefin cross-metathesis/intramol. aza-Michael addition of indolyl olefins with enones also gave the desired tetrahydropyridoindoles in excellent yields (80-96%) and enantioselectivities (88-93% ee). In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3Application of 1043567-32-3).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. Application of 1043567-32-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis