Asymmetric Organocatalytic Synthesis of Bisindoles – Scope and Derivatizations was written by Retich, Christina;Braese, Stefan. And the article was included in European Journal of Organic Chemistry in 2018.SDS of cas: 1043567-32-3 This article mentions the following:
Starting from 3-vinylindoles and glyoxylate imines, the authors created a library of diverse 4,6-bis(1H-indole-3-yl)piperidine 2-carboxylates by using 10 mol-% of a chiral phosphoric acid. Using electron-withdrawing groups on the starting material during the reaction gave Povarov-type structures, which extended the previous library of mols. Furthermore, the authors could demonstrate that consecutive reactions like reductions, cross coupling reactions or click reactions on bisindoles are feasible. In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3SDS of cas: 1043567-32-3).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. SDS of cas: 1043567-32-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis