Catalyst-Controlled Diastereodivergent Construction of Vicinal Sulfur-Functionalized Quaternary and Tertiary Stereocenters was written by Zhang, Lili;Yuan, Huijun;Lin, Wei;Cheng, Yuyu;Li, Pengfei;Li, Wenjun. And the article was included in Organic Letters in 2018.Synthetic Route of C48H29O4P This article mentions the following:
A catalyst-controlled diastereodivergence is described for the enantioselective conjugate addition of o-hydroxyphenyl-substituted p-QMs with 5H-thiazol-4-ones. The reactions were enabled by two chiral complementary, nonenantiomeric catalysts to furnish a series of adducts possessing vicinal sulfur-functionalized quaternary and tertiary stereocenters in high yields with excellent asym. induction. Moreover, o-QMs generated in situ from o-hydroxybenzyl alcs. were also compatible. In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3Synthetic Route of C48H29O4P).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. Synthetic Route of C48H29O4P
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis