Quality Control of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxoleIn 2020 ,《Ni-catalyzed enantioconvergent coupling of epoxides with alkenylboronic acids: construction of oxindoles bearing quaternary carbons》 was published in CCS Chemistry. The article was written by Wu, Liang; Yang, Guoqiang; Zhang, Wanbin. The article contains the following contents:
A nickel- nickel/bisphosphinecatalyzed stereoconvergent cross-coupling reaction of epoxides with alkenylboronic acids was developed . Racemic spiroepoxyoxindoles were converted to chiral homoallylic alcs. beared quaternary carbon stereogenic centers via a stereoablative enantioconvergent transformation. The subsequently fabricated oxindoles-carrying quaternary carbon products were obtained in good yields and enantioselectivity. A wide range of substrates and alkenylboronic acids was tolerated under the catalytic system. This reaction provided a rare example of a nickel catalyzed enantioselective cross-coupling reaction of tertiary alkyl electrophiles and an enantioconvergent transformation of racemic epoxides, beneficial as a low-cost, sustainable, and efficient catalyst in the preparation of chiral oxindole-containing natural and pharmaceutical compounds In the experiment, the researchers used many compounds, for example, (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Quality Control of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) may be used for: rhodium-catalyzed asymmetric formal olefination or cycloaddition of 1,3-dicarbonyl compounds with 1,6-diynes or 1,6-enynes, stereoselective preparation of homoallylic alcohols via Ir-catalyzed stereoselective transfer hydrogenative crotylation of an allylic acetate with alcohols or aldehydesQuality Control of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis