《Enantioselective synthesis of chiral acylsilanes by copper/HZNU-Phos-catalyzed asymmetric conjugate addition of diethyzinc to α,β-unsaturated acylsilanes》 was written by Lv, Ji-Yuan; Xu, Zheng; Zheng, Zhan-Jiang; Li, Li; Cui, Yu-Ming; Cao, Jian; Yang, Ke-Fang; Xu, Li-Wen. Application of 210169-54-3This research focused onunsaturated acylsilane preparation copper catalyzed asym conjugate addition diethyzinc; chiral acylsilane preparation. The article conveys some information:
The catalytic asym. Cu-catalyzed conjugate addition of diethylzinc to α,β-unsaturated acylsilanes proceeds smoothly in moderate to good yields and promising enantioselectivities (up to 85% ee) in the presence of the multifunctional HZNU-Phos with both a phosphine center and BINOL-based diol moiety that played a crucial role in the achievement of the best enantioselectivity for this reaction. In the experiment, the researchers used (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Application of 210169-54-3)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) is a chelating ligand used to prepare coordination complex catalysts, such as its use in Pd catalysts for the enantioselective synthesis of spiro- or benzofused hetereocycles with exocyclic olefins via enantioselective intramolecular dearomative Heck reaction of indoles, benzofurans, pyrroles and furans.Application of 210169-54-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis