In 2019,Organic Letters included an article by Zhao, Xiang; Zhang, Feng; Liu, Kai; Zhang, Xumu; Lv, Hui. Recommanded Product: 210169-54-3. The article was titled 《Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines》. The information in the text is summarized as follows:
An efficient synthetic route to chiral allylic amines R1R2C:CHCHR3NHR4 (R1 = Ph, 2-naphthyl, 2-furyl, etc; R2 = H, Me; R3 = Ph, 3-FC6H4, 4-MeOC6H4, etc.; R4 = Ms, SO2NMe2, Ts) has been developed by nickel/(S,S)-Ph-BPE complex catalyzed chemoselective asym. hydrogenation of α,β-unsaturated ketoimines. Varieties of α,β-unsaturated ketoimines have been well tolerated in this transformation to give chiral allylic amines with high yields and excellent ee values (up to 99% yield, up to 99% ee). A gram-scale reaction with 0.2 mol % catalyst loading has also been achieved. The results came from multiple reactions, including the reaction of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Recommanded Product: 210169-54-3)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) is a chelating ligand used to prepare coordination complex catalysts, such as its use in Pd catalysts for the enantioselective synthesis of spiro- or benzofused hetereocycles with exocyclic olefins via enantioselective intramolecular dearomative Heck reaction of indoles, benzofurans, pyrroles and furans.Recommanded Product: 210169-54-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis