Masutomi, Koji; Sakiyama, Norifumi; Noguchi, Keiichi; Tanaka, Ken published the artcile< Rhodium-Catalyzed Regio-, Diastereo-, and Enantioselective [2+2+2] Cycloaddition of 1,6-Enynes with Acrylamides>, COA of Formula: C44H40P2, the main research area is enyne enantioselective diastereoselective regioselective cycloaddition acrylamide rhodium BINAP catalyst; isoindole indene isobenzofuran amide hexahydro enantioselective diastereoselective synthesis.
A variety of partially hydrogenated isoindoles I [X = NTs; R1 = H, Me, Ph; R2 = H, Me, Et, Ph; R3 = R4 = Me, n-Bu, Ph; R3 = Me, R4 = MeO, Ph; R3R4 = (CH2)4] and their carbocyclic I [X = (MeO2C)2C; R1 = R2 = R3 = Me; R4 = Ph] and oxacyclic analogs I (X = O; R1 = n-pentyl; R2 = R3 = Me; R4 = Ph) was synthesized by rhodium(I)/(R)-H8-BINAP-catalyzed asym. [2 + 2 + 2] cycloaddition of 1,6-enynes II with acrylamides H2C:CHC(O)NR3R4. In this catalysis, regioselective insertion of acrylamide into a rhodacyclopentene intermediate and the coordination of the carbonyl group of acrylamide to the cationic rhodium center suppress the undesired β-hydride elimination.
Angewandte Chemie, International Edition published new progress about Alkenynes Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, COA of Formula: C44H40P2.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate