Application of 286454-86-2On March 17, 2017, Su, Hsin Y.; Taylor, Mark S. published an article in Journal of Organic Chemistry. The article was 《P-Stereogenic β-aminophosphines: preparation and applications in enantioselective organocatalysis》. The article mentions the following:
The synthesis of stereodefined β-aminophosphines ArPhPCH2CH(tBu)NH2 (1a,b, Ar = 2-MeOC6H4) having both carbon- and phosphorus-based chirality centers is described. The method involves resolution of a mixture of β-aminophosphine oxide diastereomers accessed by ring-opening of an amino alc.-derived cyclic sulfamidate. A stereospecific, borane-promoted reduction of β-aminophosphine oxides, which occurs under mild conditions and with inversion of configuration at phosphorus, is a key step in this process. The products obtained are new building blocks for the synthesis of P-chiral ligands and organocatalysts. In a proof-of-concept application in organocatalysis, the diastereomeric P-chiral β-aminophosphine-based bifunctional thioureas displayed significantly different activities in the Morita-Baylis-Hillman reaction of Me acrylate with benzaldehyde derivatives In the experiment, the researchers used many compounds, for example, (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas: 286454-86-2Application of 286454-86-2)
(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas:286454-86-2) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.Application of 286454-86-2 This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis