James, Jinju; Guiry, Patrick J. published the artcile< Highly Enantioselective Construction of Sterically Hindered α-Allyl-α-Aryl Lactones via Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation>, Electric Literature of 152140-65-3, the main research area is enantioselective preparation allyl aryl lactone; palladium catalyst decarboxylative asym allylic alkylation.
Pd-catalyzed decarboxylative asym. allylic alkylation has been developed for sterically hindered α-aryl, β-oxoallyl ester lactone substrates. Pb-mediated α-arylation of the β-oxoallyl ester was used as the key step to synthesize the substrates for catalysis in moderate to high yields. Optimization studies for decarboxylative asym. allylic alkylations (DAAA) were conducted using δ-valerolactone-derived α-aryl β-oxoallyl ester with 2,4,6-trimethoxyphenyl as the aryl substituent. Using (R,R)-ANDEN-Ph Trost as the chiral ligand, enantioselectivities of up to >99% ee and 98% ee were achieved with the six-membered and five-membered lactone substrates, resp. Bulky aryl groups containing di-ortho substitutions and naphthyl groups gave the highest enantioselectivities. This synthetic route allows for the simple modification of aryl groups, giving highly enantioselective access to important structural motifs.
ACS Catalysis published new progress about Allylic alkylation. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Electric Literature of 152140-65-3.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate