Tintas, Mihaela-Liliana; Azzouz, Rabah; Peauger, Ludovic; Gembus, Vincent; Petit, Emilie; Bailly, Laetitia; Papamicael, Cyril; Levacher, Vincent published the artcile< Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions>, SDS of cas: 152140-65-3, the main research area is enantioenriched donepezil dihydropyridine preparation anti Alzheimer activity; enantioselective Tsuji allylation organocatalysis aza ene domino.
This work aims at exploiting both the enantioselective Tsuji allylation of allyl carbonate and an organocatalytic aza-ene-type domino reaction between enal and β-enaminone to develop a straightforward access to all of the four possible stereoisomers of a donepezil-like 1,4-dihydropyridine (er up to 99.5:0.5; overall yield up 64%), an anti-Alzheimer’s prodrug candidate. This strategy was extended to the preparation of other enantioenriched 1,4-dihydropyridines (eight examples), highlighting its potential in the development of these chiral AChE inhibitors.
Journal of Organic Chemistry published new progress about Allylation (Tsuji). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, SDS of cas: 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate