Pradal, Alexandre; Chao, Chung-Meng; Vitale, Maxime R.; Toullec, Patrick Y.; Michelet, Veronique published the artcile< Asymmetric Au-catalyzed domino cyclization/nucleophile addition reactions of enynes in the presence of water, methanol and electron-rich aromatic derivatives>, Name: (S)-(+)-4,12-Bis(di(3,5-xylyl)phosphino)-[2.2]-paracyclophane, the main research area is asym gold catalyst cyclization nucleophilic addition enyne.
An efficient Au(I) catalytic system is described for the asym. domino cyclization/functionalization reactions of functionalized 1,6-enynes in the presence of an external nucleophile. The use of (R)-4-MeO-3,5-(t-Bu)2-MeOBIPHEP ligand associated with gold led to clean rearrangements implying the formal addition of an oxygen or carbon nucleophile to an alkene followed by a cyclization process. The enantiomeric excesses were highly dependent on the substrate/nucleophile combination. Very good enantiomeric excesses up to 98% were obtained in the case of substrates bearing larger groups (hindered diesters and disulfones) and in the case of hindered carbon nucleophiles.
Tetrahedron published new progress about Addition reaction catalysts, stereoselective. 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, Name: (S)-(+)-4,12-Bis(di(3,5-xylyl)phosphino)-[2.2]-paracyclophane.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate