Jolin, Trinidad; Morreale de Escobar, Gabriella published the artcile< Deiodination of L-thyroxine and its activity on the oxidation in vitro of reduced nicotinamide adenine dinucleotide by peroxidase plus hydrogen peroxide>, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is thyroxine deiodination NADH oxidation; peroxidase peroxide NADH thyroxine.
When L-thyroxine [51-48-9] activated the oxidation of disodium NADH [606-68-8] by horseradish peroxidase (EC 1.11.1.7) + hydrogen peroxide [7722-84-1], little removal of phenolic ring iodine [7553-56-2] atoms became apparent until most of the NADH had been oxidized, after which it increased markedly. This extensive deiodination was accompanied by loss of the ability of thyroxine to catalyze the oxidation of NADH by peroxidase + H2O2. ICN [506-78-5], but not I2 or thyronine [1596-67-4], catalyzed NADH oxidn in both the presence and absence of peroxidase + H2O2. Thyroxine + peroxidase + H2O2 were comparable with ICN alone in their effects on NADH oxidation The obvious results that the active moiety is the halogen liberated from thyroxine or ICN were not directly supported by some of the results obtained by measuring the degree of deiodination of thyroxine in the system. Possible explanations of these apparently contradictory conclusions were discussed.
Biochemical Journal published new progress about Deiodination. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate