In 2018,Gupta, Naveen; Tak, Rajkumar; Nazish, Mohd; Jakhar, Ajay; Khan, Noor-ul H.; Kureshy, Rukhsana I. published 《Copper(II) Triflate Catalyzed Regioselective and Enantioselective Propargylation of Isatin Derivatives by Using Allenylboronic Acid Pinacol Ester》.European Journal of Organic Chemistry published the findings.COA of Formula: C38H28O4P2 The information in the text is summarized as follows:
The authors report a simple protocol for the synthesis of homopropargyl alcs. with isatin derivatives under milder conditions for the first time. The excellent regioselectivity and yields were observed with copper triflate as a Lewis-acid catalyst and allenylboronic acid pinacol ester as a nucleophile in aqueous media. A gram-scale synthesis was done to check the efficiency of the protocol with retention in selectivity. Further one-step functionalization of these homopropargyl alcs. was established as the synthetic application of these alkynes. The enantioselective synthesis of these chiral propargyl alcs. also was explored for the first time with an enantiomeric ratio up to 12:88. In the experiment, the researchers used many compounds, for example, (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3COA of Formula: C38H28O4P2)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) may be used for: rhodium-catalyzed asymmetric formal olefination or cycloaddition of 1,3-dicarbonyl compounds with 1,6-diynes or 1,6-enynes, stereoselective preparation of homoallylic alcohols via Ir-catalyzed stereoselective transfer hydrogenative crotylation of an allylic acetate with alcohols or aldehydesCOA of Formula: C38H28O4P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis