Product Details of 210169-54-3In 2022 ,《Catalytic Regio- and Enantioselective Protonation for the Synthesis of Chiral Allenes: Synergistic Effect of the Counterion and Water》 was published in Angewandte Chemie, International Edition. The article was written by Lin, Qianchi; Zheng, Sujuan; Chen, Long; Wu, Jin; Li, Jinzhao; Liu, Peizhi; Dong, Shunxi; Liu, Xiaohua; Peng, Qian; Feng, Xiaoming. The article contains the following contents:
A highly enantioselective tandem Pudovik addition/[1,2]-phospha-Brook rearrangement of α-alkynylketoamides with diarylphosphine oxides was achieved with a N,N’-dioxide/ScIII complex as the catalyst. This protocol features broad substrate scope, high regio- and enantioselectivity, and good functional-group compatibility, providing a straightforward route to various trisubstituted allenes with a diarylphosphinate functionality in good yields with high enantioselectivities (up to 97% yield, 96% ee). Control experiments and theor. calculations revealed that a synergistic effect of the counterion and water was critical for the regio- and enantioselective protonation after [1,2]-phospha-Brook rearrangement. The synthetic utility of this methodol. was demonstrated by the conversion of products into complex bridged polycyclic architectures through intramol. dearomatizing arene/allene cycloaddition The experimental part of the paper was very detailed, including the reaction process of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Product Details of 210169-54-3)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) is a chelating ligand used to prepare coordination complex catalysts, such as its use in Pd catalysts for the enantioselective synthesis of spiro- or benzofused hetereocycles with exocyclic olefins via enantioselective intramolecular dearomative Heck reaction of indoles, benzofurans, pyrroles and furans.Product Details of 210169-54-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis