《Tandem Catalytic Indolization/Enantioconvergent Substitution of Alcohols by Borrowing Hydrogen to Access Tricyclic Indoles》 was written by Yang, Guoqiang; Pan, Jiaoting; Ke, Ya-Ming; Liu, Yongbing; Zhao, Yu. Name: (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxoleThis research focused ontricyclic indole preparation enantioselective; alc alkynyl aniline tandem indolization iridium phosphoric acid catalyst; enantioselectivity; hydrogen; redox-neutral catalysis; relay catalysis; tricyclic indoles. The article conveys some information:
An efficient tandem catalysis method is achieved for the direct conversion of alc.-containing alkynyl anilines 2-H2N-5-RC6H3CC(CH2)3CH(R1)OH (R = H, Me, t-Bu, F; R1 = Bu, cyclohexylmethyl, Ph, 2-naphthyl, furan-2-yl, etc.) to valuable chiral 2,3-fused tricyclic indoles (S)-I. This method relies on a tandem indolization followed by enantioconvergent substitution of alcs. via borrowing hydrogen to construct two rings in one step, enabled by relay and cooperative catalysis of a chiral iridium complex with a chiral phosphoric acid. Highly diastereoselective transformations of the tricyclic indole products (S)-I (R = H; R1 = isobutyl) also provide efficient access to a diverse array of complex polycyclic indoline compounds, e.g., II. In the experiment, the researchers used many compounds, for example, (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Name: (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) is a chelating ligand used to prepare coordination complex catalysts, such as its use in Pd catalysts for the enantioselective synthesis of spiro- or benzofused hetereocycles with exocyclic olefins via enantioselective intramolecular dearomative Heck reaction of indoles, benzofurans, pyrroles and furans.Name: (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis