COA of Formula: C22H22NPOn November 30, 2007 ,《Highly enantioselective synthesis of α-hydroxy phosphonic acid derivatives by Rh-catalyzed asymmetric hydrogenation with phosphine-phosphoramidite ligands》 appeared in Angewandte Chemie, International Edition. The author of the article were Wang, Dao-Yong; Hu, Xiang-Ping; Huang, Jia-Di; Deng, Jun; Yu, Sai-bo; Duan, Zheng-Chao; Xu, Xue-Feng; Zheng, Zhuo. The article conveys some information:
Unsym. hybrid phosphine-phosphoramidite ligands, e.g. PhCH2CH(OBz)P(O)(OMe)2, with central and axial chirality are applied to the highly enantioselective hydrogenation of various enol ester phosphonates, e.g. PhCH:C(OBz)P(O)(OMe)2. Enantioselectivities up to 99.9% ee are obtained for all classes of β-aryl, β-alkoxy, and β-alkyl substrates. In the experiment, the researchers used (R)-8-(Diphenylphosphino)-1,2,3,4-tetrahydronaphthalen-1-amine(cas: 960128-64-7COA of Formula: C22H22NP)
(R)-8-(Diphenylphosphino)-1,2,3,4-tetrahydronaphthalen-1-amine(cas:960128-64-7) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.COA of Formula: C22H22NP This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis