Akula, Ramulu; Doran, Robert; Guiry, Patrick J. published the artcile< Highly enantioselective formation of α-allyl-α-arylcyclopentanones via Pd-catalysed decarboxylative asymmetric allylic alkylation>, Category: chiral-phosphine-ligands, the main research area is allyl alpha arylcyclopentanone enantioselective preparation; alpha aryl beta ketoester asym allylic alkylation ANDEN Trost; allylic alkylation; asymmetric catalysis; decarboxylation; natural products; palladium.
A highly enantioselective Pd-catalyzed decarboxylative asym. allylic alkylation of cyclopentanone derived α-aryl-β-keto esters employing the (R,R)-ANDEN-Ph Trost ligand was developed. The product (S)-α-allyl-α-arylcyclopentanones, e.g., I [Ar = 2,4,6-(MeO)3C6H2, 2,6-(MeO)2C6H3, 2,4-(MeO)2C6H3, etc.] were obtained in excellent yields and enantioselectivities (up to >99.9 % ee). This represented one of the most highly enantioselective formations of an all-carbon quaternary stereogenic center reported to date. This reaction was demonstrated on a 4.0 mmol scale without any deterioration of enantioselectivity and was exploited as the key enantioselective transformation in an asym. formal synthesis of the natural product (+)-tanikolide.
Chemistry – A European Journal published new progress about Allyl group. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Category: chiral-phosphine-ligands.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate