Alexy, Eric J.; Virgil, Scott C.; Bartberger, Michael D.; Stoltz, Brian M. published the artcile< Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic α-Quaternary Ketones>, Application In Synthesis of 152140-65-3, the main research area is thiopyranone enantioselective decarboxylative allylic alkylation palladium reduction; acyclic stereogenic quaternary ketone enantioselective preparation; palladium enantioselective decarboxylative allylic alkylation catalyst.
A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The α-quaternary 4-thiopyranones produced are challenging to access by standard enolate alkylation owing to facile ring-opening β-sulfur elimination. In addition, reduction of the carbon-sulfur bonds provides access to elusive acyclic α-quaternary ketones. The alkylated products, e.g. I, were obtained in up to 92% yield and 94% enantiomeric excess.
Organic Letters published new progress about Allylic alkylation (enantioselective, decarboxylative). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Application In Synthesis of 152140-65-3.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate