1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EMBODIMENT I (1R,cis)-2-[2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropyl]ethanal dimethyl acetal Tri(dimethylamino)phosphine (168.3 mmol) was added over a period of 12 minutes to a stirred solution of carbon tetrachloride (167.4 mmol) in pentane (360 ml) kept at 0 C. under nitrogen in a 1-liter flask. Then, the mixture in the flask was stirred for 30 minutes at 0 C. This finished the first step. At 0 C. (1R,cis)-2-(2,2-dimethoxyethyl)-3,3-dimethylcyclopropanecarbaldehyde (66.4 mmol) was added dropwise to the suspension in the flask over a period of nine minutes. The temperature was increased to 12 C. over a period of 15 minutes and stirring was continued at the temperature for a further 15 minutes. This finished the second step. Then water (75 ml) was added at 12 C. and–after removal of the aqueous phase–the organic phase was washed with two 35-ml portions of water. The washed organic phase was dried over anhydrous magnesium sulphate and the solvent was evaporated from the dried solution to give a residue (17.4 g) containing the desired product (100% (1R,cis), purity 88%, yield 91.1%). The NMR spectrum of the desired product showed the following absorptions: delta=1.00 ppm singlet H3 C–C–CH3 delta=3.33 ppm singlet C–(O–CH3)2 delta=5.59 ppm doublet C=CH delta=1.13 ppm singlet H3 C–C–CH3 delta=4.33 ppm triplet (H3 C–O)2 –CH– multiplets for the two H atoms bound to the ring and for HC–CH2 –CH., 1608-26-0
The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shell Oil Company; US4298757; (1981); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate