Liu, Yuanhao;Lu, Yunlong;Xu, Zhongren;Ma, Xiaoyan;Chen, Xiuli;Liu, Wukun published 《Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics》. The research results were published in《Drug Discovery Today》 in 2022.Synthetic Route of C20H36AuO9PS The article conveys some information:
A review. Multidrug resistance (MDR) is a significant issue associated with the clin. application of antibiotics. It is also challenging to discover and develop new antibiotics with novel scaffolds. Therefore, the repurposing of existing drugs has become a promising strategy for antibiotic drug discovery. Auranofin, an approved gold metallic drug, has been used for the treatment of rheumatoid arthritis (RA) for many years. Recent research revealed that auranofin has strong antibacterial activity against multiple Gram-pos. bacteria by inhibiting thioredoxin reductase (TrxR). These results inspired the development of gold complexes as antibacterial agents. Herein, we discuss recent advances in the development of auranofin and other gold complexes as antibacterial agents, providing a new viewpoint for the treatment of bacterial infection.((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold (cas: 34031-32-8) were involved in the experimental procedure.
((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold(cas: 34031-32-8) is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.Synthetic Route of C20H36AuO9PS
Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis