The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ) is researched.Recommanded Product: 1-(Bromomethyl)-2-iodobenzene.Luo, Xiai; Zhou, Liwei; Lu, Haiyan; Deng, Guobo; Liang, Yun; Yang, Chunming; Yang, Yuan published the article 《Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones》 about this compound( cas:40400-13-3 ) in Organic Letters. Keywords: fused isoquinolinedione isoquinolinone preparation regioselective; alkene aryl iodide bromobenzoic acid domino cyclization palladium catalyst; carbon hydrogen activation Heck reaction decarboxylation. Let’s learn more about this compound (cas:40400-13-3).
A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.
The article 《Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones》 also mentions many details about this compound(40400-13-3)Recommanded Product: 1-(Bromomethyl)-2-iodobenzene, you can pay attention to it, because details determine success or failure
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate