With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.
2.679 g (8.635 mmol) of Rh(COD)(acac) was mixed with 20 ml of MEK in a 0.1 litre Schlenk flask. To the resulting slurry was added by syringe 1.22 ml of neat 54percent wt tetrafluoroboric acid in diethylether (8.74 mmol) by syringe over a period of 2 minutes, resulting in a red solution. After 5 minutes, 1.17 ml (9.66 mmol) of 1,5-cyclooctadiene was added by syringe. The brown red slurry was stirred for 20 minutes. Then 4.65 g (8.635 mmol) of DPEPhos was added in 2 portions over a period of 3 minutes. A orange slurry resulted after 5 minutes. The stirred slurry was reduced by evaporating MEK solvent until a slurry of the cationic complex in about 10 ml of residual solvent was obtained. To this slurry was added 20 ml of ethanol. The resulting orange slurry was degassed and stirred at room temperature for 1 hour before being filtered and washed with 2×5 ml of cold ethanol. After drying overnight (1 mbar, 2O0C), gave 7.26 g of complex [Rh cod DPEPhos] BF4 with approximately 0.75 equivalents of ethanol , Yield = 98.5 percent (8.51 mmol)., 166330-10-5
The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; NEDDEN, Hans Guenter; WO2010/1173; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate