In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of N-Aroyl Diketone/Triketone Derivatives as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibiting-Based Herbicides, published in 2019-10-30, which mentions a compound: 49609-84-9, mainly applied to aroyl diketone triketone derivative preparation hydroxyphenylpyruvatedioxygenase inhibitor herbicide; 4-hydroxyphenylpyruvate dioxygenase; N-aroyl diketone/triketone; herbicidal activity; molecular docking; rationally designed, Quality Control of 2-Chloronicotinoyl chloride.
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most promising targets for the discovery of new bleaching herbicides. To discover novel HPPD inhibitors with excellent herbicidal activity, a series of novel N-aroyl diketone/triketone derivatives were rationally designed by splicing active groups and bioisosterism. All the compounds were characterized by IR, 1H and 13C NMR, and high-resolution mass spectrometry. Bioassays revealed that most of these derivatives displayed preferable herbicidal activity against Echinochloa crus-galli at 0.045 mmol/m2 and Abutilon juncea at 0.090 mmol/m2. In particular, compound (I) was more potent compared with the commercialized compound mesotrione. Mol. docking indicated that the corresponding active mols. of target compounds and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD. These promising findings demonstrate that these compounds could be considered as potential herbicide candidates for further development of novel HPPD inhibitors.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloronicotinoyl chloride)Quality Control of 2-Chloronicotinoyl chloride, illustrating the importance and wide applicability of this compound(49609-84-9).
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate