Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about A palladium-catalyzed Heck/[4+1] decarboxylative cyclization cascade to access diverse heteropolycycles by using α-bromoacrylic acids as C1 insertion units.Application In Synthesis of 1-(Bromomethyl)-2-iodobenzene.
A novel palladium-catalyzed Heck/[4+1] decarboxylative cyclization cascade of alkene-tethered aryl iodides 2-I-4-R2-5-R1-6-RC6HC(X)N(R3)C(Y)C(R4)=CH2 (R = H, Me; R1 = H, F, Cl, OMe, etc.; R2 = H, Me; R3 = Me, benzyl, allyl; R4 = Me, Ph; X = C(O), CH2; Y = C(O), CH2) and I (R5 = H, Me; R6 = H, Me, F, Cl, Br; R7 = H, Me; Z = C(O)) with α-bromoacrylic acids HOOC(Br)C=C(R8)(R9) [R8 = H, Me, Ph, etc.; R9 = H, Pr, 4-chlorophenyl, etc.; R8R9 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-, etc.] is reported. This strategy employs α-bromoacrylic acids as a new C1 synthon to assemble diverse heteropolycycles, such as cyclopenta[de]isoquinolinediones II and cyclopenta[de]indolo[2,1-a]isoquinolinones III, in moderate to excellent yields. This reaction enables the construction of three C-C bonds via sequential fused palladacycle formation, C(vinyl)-Br bond activation and decarboxylation.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate