In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Intramolecular palladium(II)/(IV) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group, published in 2019, which mentions a compound: 40400-13-3, mainly applied to indane aldehyde preparation; tertiary aldehyde arylation palladium imine catalyst, Application In Synthesis of 1-(Bromomethyl)-2-iodobenzene.
Palladium catalyzed β-C(sp3)-H activation of tertiary aldehydes RCH2C(R1)(R2)CHO [R = 2-Br-5-ClC6H3, 2-IC6H4, 2-Br-4-H3COC6H3, etc.; R1 = Me, Et, n-Pr; R2 = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R4 = H, 5-F, 4-Cl, 5-CF3, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step.
Here is just a brief introduction to this compound(40400-13-3)Application In Synthesis of 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate