The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium( cas:172418-32-5 ) is researched.Product Details of 172418-32-5.Tietze, Lutz F.; Petersen, Sonke published the article 《Stereoselective synthesis of novel 19-nor-steroids by a double Heck reaction》 about this compound( cas:172418-32-5 ) in European Journal of Organic Chemistry. Keywords: estrane norsteroid preparation Heck cyclization vinylation catalyst. Let’s learn more about this compound (cas:172418-32-5).
The estrane I was synthesized by two successive Heck reactions starting from enantiopure II and the cyclohexenone III, which contains a (Z)-bromovinyl group. The first intermol. Pd-catalyzed reaction leads to IV in a highly regio- and diastereoselective manner. Transformation of the enone IV to give the corresponding enol triflate followed by an intramol. Heck reaction affords the cyclized product I with an unusual cis-junction of the rings B and C in high yield.
Here is just a brief introduction to this compound(172418-32-5)Product Details of 172418-32-5, more information about the compound(trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium) is in the article, you can click the link below.
Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate