Recommanded Product: 1-(Bromomethyl)-2-iodobenzene. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about An Efficient Route to Isochromene Derivatives via Cascade Radical Cyclization and Radical-Radical Coupling. Author is Yu, Kaili; Li, Minyan; Deng, Guogang; Liu, Chunxiang; Wang, Jing; Liu, Zhengfen; Zhang, Hongbin; Yang, Xiaodong; Walsh, Patrick J..
Isochromene synthesis is generally limited to cyclization of Ph propargyl ether precursors under transition metal catalyzed conditions. Herein, authors present a novel disconnection that rapidly constructs isochromene derivatives I (R1 = H, 7-Me, 7-F, etc.; R2 = H, Me, C6H5; R3 = H, Me) and II (Ar = 4-MeC6H4, 4-FC6H4, 2-pyridyl, etc.) through a cascade radical cyclization strategy. Generation of aryl radicals by SET reduction of 2-iodo benzyl allenyl ethers is followed by radical cyclization to construct the isochromene core with formation of an allylic radical. The allylic radical then undergoes coupling with the azaallyl radical to give products in good to excellent yields. The elaborated 2-iodo Ph propargyl ether precursors can be used to construct isochromenes bearing various functional groups.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate