Product Details of 172418-32-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: trans-Di-μ-acetatobis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium, is researched, Molecular C46H46O4P2Pd2, CAS is 172418-32-5, about Microwave-Promoted Aminocarbonylation of Aryl Iodides, Aryl Bromides, and Aryl Chlorides in Water. Author is Wu, Xiongyu; Ekegren, Jenny K.; Larhed, Mats.
Fast and direct methods were developed for the small-scale carbonylative preparation of benzamides from aryl iodides, bromides, and chlorides in pure H2O. The reactions proceed by Pd catalysis using noninert conditions, solid Mo(CO)6 as the CO source, and controlled microwave superheating. Within 15 min of microwave processing, >90 aminocarbonylations were successfully performed in useful to excellent yields employing both primary and secondary amines. Using appropriate ratios of starting amines and aryl halides, the competing hydroxycarbonylation reaction was suppressed and only trace amounts of the corresponding carboxylic acids were detected. Based on this aqueous carbonylation, a facile preparation of a novel HIV-1 protease inhibitor was achieved.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate