What kind of challenge would you like to see in a future of compound: 40400-13-3

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 40400-13-3, is researched, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrIJournal, Article, Bioorganic & Medicinal Chemistry Letters called Discovery of stereospecific cytotoxicity of (8R,8’R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring, Author is Yamauchi, Satoshi; Nishimoto, Asuka; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya, the main research direction is lignan arctigenin insect cells 28S rRNA structure activity relationship; 28S rRNA; Arctigenin; Insect cells; Lignan; Structure-activity relationship.Application of 40400-13-3.

One of the arctigenin stereoisomers, (8R,8’R)-trans-form 1, showed stereospecific cytotoxicity against insect cells, Sf9 and NIAS-AeAl-2 cells. By the comparison with other stereoisomers, the most importance of the 8’R stereochem. for the higher activities was clarified. On the other hand, the wider range of activity level among stereoisomers against cancer cells, HL-60, was not observed The structure-activity relationship research using derivatives bearing (8R,8’R)-trans-form was performed to show the same level of activities of 3-iodo, 4-iodo, and 3,4-methylenedioxy derivatives 28, 29, and 36 as (8R,8’R)-trans-arctigenin 1. In the examination of thiono derivatives, 4-iodo thiono and 3,4-methylenedioxy thiono derivatives 66, 67 showed similar level of activities to that of (8R,8’R)-trans-arctigenin 1. The expression of ribosomal 28S rRNA gene of Sf9 cells was increased by (8R,8’R)-trans-arctigenin 1, whereas a degradation of DNA was not observed

Here is a brief introduction to this compound(40400-13-3)Application of 40400-13-3, if you want to know about other compounds related to this compound(40400-13-3), you can read my other articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate