With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.
A solution of the ligand DPEphos (0.355g, 0.66 mmol) in30 mL of dichloromethane was added drop by drop to a solution of CoCl2.6H2O (0.166g, 0.70 mmol) in 50 mL dichloromethane. The reaction mixture was refluxed under nitrogen for 1 h. After cooling the reaction mixture, the solvent was evaporated and the resultant solid mass was washed several times with ether and hexane. Finally, after drying under vacuum,a blue compound was obtained which was re-crystallized from dichloromethane. Yield: 90percent. Anal. Calcd. forC36H28Cl2OP2Co (percent): C, 64.69; H, 4.22, Co, 8.82; Found: C,64.12; H, 4.19; Co, 8.78; Selected peak assignments in MSESIm/z (percent): 1360 (5), [2M+Na]+; 1301 (30), [2M-Cl]+; 746(20), [M+2K]2+; 690 (30) [M+Na]+; 539 (50), [DPEphos]+;Selected IR frequencies (cm-1, KBr): 3051, 2985 (C-H);1485, 1435 (C=C); 1101 (C-O-C); 506 (Co-P); 336, 322 (Co-Cl) ); UV-Vis (CH2Cl2), max (nm): 246, 647, 713., 166330-10-5
As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.
Reference£º
Article; Sahu, Debojeet; Banik, Biplab; Borah, Malabika; Das, Pankaj; Letters in Organic Chemistry; vol. 11; 9; (2014); p. 671 – 676;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate