With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.
In a nitrogen atmosphere, in a glove box, Add 0.01 mmol of nickel chloride and 0.52 mmol of bis-naphthylphosphine, respectively. 1.5 equivalents of t-BuOK (potassium tert-butoxide), sequentially added to the Schlenk reaction tube, Subsequently, 0.4 mmol of phenylpropanonitrile compound was added,Vacuuming and backfilling with nitrogen; under a nitrogen atmosphere, The solvent was added to 3 ml of 1,4-dioxane, and the reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. That is the target product: Phenylethylnaphthylphosphine oxide with a yield of 99%., 13440-07-8
The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hunan University; Zhang Jishu; Qi Tafamingrenqingqiubugongkaixingming; (13 pag.)CN109438512; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate