With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
Example 3 Synthesis of TMPO The following is an exemplary procedure for the synthesis of tris(4-methoxyphenyl)phosphine oxide (TMPO, VI) as depicted in . Into a 100 mL three-necked flask equipped with a magnetic stir bar and nitrogen inlet and outlet were placed tris(4-methoxyphenyl)phosphine (TMP, V) (3.0 g, 8.5 mmol) and acetone (30 mL). A mixture of water (2 mL) and H2O2 (35%, 1 mL, 9 mmol) was added slowly. After the mixture had been stirred at room temperature for 1 hour, the acetone was evaporated, and methylene chloride (50 mL) was added. The organic phase was washed with a saturated NaCl solution (35 mL) three times with the aid of a separatory funnel. The organic layer was then dried over anhydrous sodium sulfate. Finally, the solvent was removed via rotary evaporation to afford 3.0 g (95%) of a white solid, m.p. 144.7-145.4 C. MS (m/e): 368 (M+). Anal. Calcd. for C21H21O4P: C, 68.47%; H, 5.75%; P, 8.41%. Found: C, 68.42%; H, 5.72%; P, 8.11%. FT-IR (KBr, cm-1): 3068, 3026, 2959, 2837, 1597, 1569, 1503, 1468, 1289, 1254, 1179, 1121, 1019, 803, 671, 543. 1H-NMR (CDCl3, delta in ppm): 3.84 (s, 6H, CH3), 6.94-6.97 (dd, 6H, Ar-H), 7.54-7.60 (dd, 6H, Ar-H). 13C-NMR (DMSO-d6, delta in ppm): 55.29, 114.08, 114.21, 124.19, 125.28, 133.21, 133.32, 161.79, 161.82.
855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; The United States of America as represented by the Secretary of The Air Force; Tan, Loon-Seng; Wang, David Huabin; US8546614; (2013); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate