A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 131211-27-3, Name is Di(adamantan-1-yl)phosphine, molecular formula is C20H31P. In a Article，once mentioned of 131211-27-3, Quality Control of: Di(adamantan-1-yl)phosphine
A highly enantioselective intermolecular hydrophosphination reaction is described. The (Pigiphos)-nickel(II)-catalyzed reaction of secondary phosphines and methacrylonitrile gives chiral 2-cyanopropylphosphines in good yield and high enantiomeric excess (ee’s up to 94%; (R)-(S)-Pigiphos = bis{(R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyl}cyclohexylphos phine). We propose a mechanism involving coordination of methacrylonitrile to the dicationic nickel catalyst followed by 1,4-addition of the phosphine, and then, rate-determining proton transfer. This mechanism is supported by (a) the experimentally determined rate law (rate = K[Ni][methacrylonitrile][t-Bu 2PH]), (b) a large primary deuterium isotope effect K H/KD = 4.6(1) for the addition of t-Bu2PH(D) at 28.3C in toluene-d8, (c) the isolation and characterization of the species [Ni(K3-Pigiphos)(KN-methacrylonitrile)]2+, and (d) DFT calculations of model compounds.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.HPLC of Formula: C20H31P, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 131211-27-3, in my other articles.
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate