With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.
General procedure: To a well-stirred solution of compounds (2a-2b) (2mmol) in anhydrous toluene (15 mL) was added hexamethylphosphoroustriamide (2mmol). The mixture was heated under reflux for 12 h. Silica gel TLC indicated the completion of the reaction. The solvent was evaporated under reduced pressure, and the residue was purified on silica gel preparative TLC using ethyl acetate as eluent. A mixture of compounds (3a-3b) (1mmol), S8 (5 mmol) and anhydrous toluene (10mL) was refluxed for 4h, and then cooled. The sulfur excess was filtered off, and the solvent was removed under reduced pressure. Flash column chromatography on silica gelusing petroleum ether as eluant affords (4a-4b)., 1608-26-0
The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Balti, Monaem; Efrit, Mohamed Lotfi; Journal of Sulfur Chemistry; vol. 37; 4; (2016); p. 466 – 475;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate