With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.
General procedure: The synthesis is similar to 2, with PPh3 being replaced by dppf(1.1 g, 2.0 mmol). The residue was purified by column chromatographyon silica gel (eluent: CH2Cl2/CH3OH, 30:1, V/V) to give abrown-yellow solid. Yield: 0.75 g, 72percent. 1H NMR (500 MHz, CDCl3)d 9.18 (d, J 8.2 Hz, 2H, ePhH), 8.63 (d, J 8.5 Hz, 2H, ePhH), 8.08(d, J 8.3 Hz, 2H, ePhH), 7.73e7.60 (m, 10H, ePhH), 7.56 (td, J 7.3,1.2 Hz, 4H, ePhH), 7.49e7.40 (m, 8H, ePhH), 6.29 (d, J 8.4 Hz, 2H,ePhH), 4.49 (s, 4H, eCpH), 4.20 (dd, J 8.2, 6.2 Hz, 8H, eCH2CH2e,eCpH), 1.73 (dt, J 15.2, 7.6 Hz, 4H, eCH2CH2e), 1.52e1.42 (m, 4H,eCH2CH2e), 0.99 (t, J 7.4 Hz, 6H, eCH2CH3). 13C NMR (125 MHz,Scheme 1.CDCl3) d 165.15, 164.40, 157.03, 133.29, 132.50, 131.90, 131.82, 131.31,131.17, 130.58, 129.82, 129.42, 129.23, 128.98, 128.91, 128.81, 124.08,122.48, 115.10, 114.99, 109.74, 74.39, 39.87, 30.39, 29.68, 20.46,13.90. 31P NMR (200 MHz, CDCl3) d 9.40. MS calcd for C66H56Fe-N4O5P2Na [MNa]: 1109.31, found: 1109.4., 12150-46-8
As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.
Reference£º
Article; Xu, Shou De; Fang, Cheng Hui; Tian, Guang Xuan; Chen, Yi; Dou, Ye Hong; Kou, Jun Feng; Wu, Xiang Hua; Journal of Molecular Structure; vol. 1102; (2015); p. 197 – 202;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate