17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Compounds 1d? was prepared according to the reported procedures.2 The 1d? (320 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed invacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-benztriazole-1-N,N,N?,N?-tetraethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol),followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 18 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried over Na2SO4. The solvent was removed in vacuo to afford the crude product as colourless oil, which was purified by flash chromatography (15percent EtOAc in hexanes) yielding the precat 1d (356 mg, 70percent), 17261-28-8
As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.
Reference£º
Article; Zhou, Zhipeng; Zheng, Xiaojun; Liu, Jialin; Li, Jinlei; Wen, Pushan; Wang, Haifei; Synlett; vol. 28; 8; (2017); p. 999 – 1003;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate