With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
Into a 1 L three-neck round-bottom flask equipped with a 250 mL addition funnel, a reflux condenser and a nitrogen inlet, 70 g of recrystallized tri(4-methoxyphenyl)phosphorus and 300 mL of dry THF were added. To the solution, 2.8 g of thin lithium pieces were added at 25 C. under nitrogen with stirring. LiP(4-OMe-Ph)2 was immediately formed in the solution, and the solution turned to a deep reddish yellow color while a large amount of heat was generated. The temperature of the solution was elevated slowly to 55 C. for 1 hour, and the solution was cooled again to 25 C. for 2 hours with stirring. The formed 4-methoxyphenyllithium was decomposed by dropwise adding 18.5 g of distilled and purified t-butylchloride for 45 min. The transparent reddish yellow solution was boiled for 5 min, and then cooled again to -4 C.
As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.
Reference£º
Patent; SK GLOBAL CHEMICAL CO., LTD.; SK INNOVATION CO., LTD.; US2012/130086; (2012); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate