Reference of 17261-28-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 17261-28-8, Name is 2-(Diphenylphosphino)benzoic acid
A 2-carbonyl-4-olefin-5-bromo -1,3-oxazine and the application of the synthetic method of the compound of (by machine translation)
The present invention provides 2-carbonyl-4-olefin-5-bromo -1,3-oxazine compounds and its synthetic method and application. The method comprises: the trifluoromethane sulfonic acid scandium/phosphorus-oxygen ligand and partially under the action of the sodium chloride, the compound of the formula I with by reacting a dihydroxy base sea, shown in formula II is 2-carbonyl-4-olefin-5-bromo -1,3-oxazine compounds. The invention of the formula I with different structure compound and shows a dihydroxy base sea because raw materials, the trifluoromethane sulfonic acid scandium/phosphorus-oxygen ligand and partially under the action of the sodium chloride, the effective synthesis of optically active 2-carbonyl-4-olefin-5-bromo -1,3-oxazine compounds. This kind of compound through the past carbo- split-ring can be very convenient to obtain various containing 1,3-azanol the compounds of structure, at the same time can also be in the reaction for the introduction of a olefin and bromine atom, these functional groups can be further transformed, the introduction of other functional group, has great application value. The method of the invention the raw materials are easy to synthesize, mild reaction conditions, the operation is simple, regional high selectivity, enantiomer excess can be up to 99%, the output is high up to 91%. (by machine translation)
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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate