With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.
To an ice-cold solution of methyl alcohol (6 mL, 1.2 mmol) in toluene (13 mL), a solution of chlorodiphenylphosphine (0.25 mL, 1.38 mmol) in toluene (3 mL) was added dropwise. After 40 min stirring, azide 5 (440 mg, 1.2 mmol) was added as a solid. The obtained mixture was heated at 60 C for 40 min and then kept at room temperature for 12 h. The collected precipitate was analytically pure product 6 (300 mg, 48%). Crystals suitable for X-ray diffraction were obtained by crystallization from MeCN-DMF (3 : 1). M.p. 245 C. Found (%): P, 5.66. C27H21BrN3O2. Calculated (%): P, 5.70. IR (KBr), nu/cm-1: 1706 (C=O), 1606 (C=N), 3346 (NH). 31P NMR (DMSO-d6), delta: 23.45. 1H NMR (DMSO-d6), delta: 4.72-4.76 (m, 1 H, CHNP); 6.43-7.97 (m, 8 H, Ar); 11.01 (s, 1 H, NH).
1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Gololobov, Yu. G.; Krasnova, I. Yu.; Barabanov; Fedyanin; Andronati; Pavlovskii; Russian Chemical Bulletin; vol. 64; 1; (2015); p. 233 – 236; Izv. Akad. Nauk, Ser. Khim.; 1; (2015); p. 233 – 236,4;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate