12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 12150-46-8, Recommanded Product: 1,1-Bis(diphenylphosphino)ferrocene
Abstract: Reaction of Na2[PdCl4] with two equivalents of 4,5-benzo-3H-1,2-dithiole-3-thione (btt) affords cis-[PdCl2(kappa1-btt)2] (1), which provides a convenient entry into mixed-ligand btt complexes. Addition of one equivalent of a range of diamines or diphosphines gives the salts [Pd(kappa1-btt)2(kappa2-diamine)]Cl2 (2a?d) (diamine = en, dap, bipy, phen) and [Pd(btt)2(kappa2-diphosphine)]Cl2 (3a?c) (diphosphine = dppe, dppp, dppf) in good yields. In contrast, two equivalents of dppm result in [Pd(kappa1-btt)2(kappa1-dppm)2]Cl2 (4), where the diphosphine binds in a monodentate fashion. Two equivalents of PPh3 result in a mixture of cis- and trans-isomers of [Pd(kappa1-btt)2(PPh3)2]Cl2 (5a?b) (ca. 1:5 ratio); the pure trans-isomer 5b was isolated by ion-exchange chromatography. The cis-isomer 5a could be synthesized independently from the reaction of cis-[PdCl2(PPh3)2] with two equivalents of btt. In all of these complexes, the btt ligand binds in a monodentate manner through the exocyclic thione sulfur. The anti-tumor activities of representative examples, cis-[PdCl2(kappa1-btt)2] (1), cis-[Pd(kappa1-btt)2(kappa1-dppm)2]Cl2 (4) and cis-[Pd(kappa1-btt)2(PPh3)2] (5a), were evaluated by cell proliferation assays and phase-contrast microscopy against prostate cancer cell lines PC3, DU145 and LNCaP, with complexes 1 and 4 showing potent anti-proliferative effects (TGI values of 19.2 and 21.1?mug/mL, respectively) against LnCaP cells. Graphical abstract: [Figure not available: see fulltext.].
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 1,1-Bis(diphenylphosphino)ferrocene. In my other articles, you can also check out more blogs about 12150-46-8
Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate