Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, 51805-45-9, Name is 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, molecular formula is C9H16ClO6P, belongs to chiral-phosphine-ligands compound. In a document, author is Zagidullin, A. A., introduce the new discover.
P-Chiral 1,7-diphosphanorbornenes: from asymmetric phospha-Diels-Alder reactions towards applications in asymmetric catalysis
A straightforward synthesis of P-chiral polycyclic phosphines by an asymmetric Diels-Alder reaction of 1-alkyl-1,2-diphospholes and (5R)-(l-menthyloxy)-2(5H)-furanone (MOxF) is presented. The [4 + 2] cycloaddition reaction of 1,2-diphospholes 1-3 with MOxF (4) proceeded with high diastereoselectivity (de up to 90%) resulting in the corresponding enantiopure anti-endo-1,7-diphosphanorbornenes 5a-7a. The absolute configuration of 5-7 was proved by a variety of 1D/2D NMR correlation methods. The use of the anti-endo-1,7-diphosphanorbornene 5a in the Pd-catalyzed asymmetric allylic alkylation of cinnamyl acetate 8 with cyclic -ketoesters 9a,b provided up to 52% ee.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 51805-45-9. Name: 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate