Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, molecular formula is , belongs to chiral-phosphine-ligands compound. In a document, author is Nikitin, Kirill, Product Details of 18437-78-0.
Dynamic Cross-Exchange in Halophosphonium Species: Direct Observation of Stereochemical Inversion in the Course of an S(N)2 Process
The complex fluxional interconversions between otherwise very similar phosphonium bromides and chlorides R3PX+X- (R = Alk, Ar, X = Cl or Br) were studied by NMR techniques. Their energy barriers are typically ca. 11 kcal mol(-1), but rise rapidly as bulky groups are attached to phosphorus, revealing the importance of steric factors. In contrast, electronic effects, as measured by Hammett analysis, are modest (rho 1.46) but still clearly indicate negative charge flow towards phosphorus in the transition state. Most significantly, detailed analysis of the exchange pathways unequivocally, and for the first time in any such process, shows that nucleophilic attack of the nucleophilic anion on the tetrahedral centre results in inversion of configuration.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 18437-78-0, in my other articles. Product Details of 18437-78-0.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate